Cyclotrons^® 11 is a fixed-energy cyclotron that accelerates negative ions up to 11 MeV.

Optmimized configuration

The Cyclotrons^® 11 design minimizes overall operating costs and building space requirements with its self- shielding solution.

Optimized production

The Cyclotrons^® 11 covers all major needs of stand-alone PET centers.

Optmimized operation

The Cyclotrons^® 11 design is optimized for hospital environment, aiming for an industry proven system.

Customer Voice
Dr. Horacio Amaral
President of Positronpharma
Chile

“The IBA Cyclone^® 11 combines the small footprint of a low-energy ymachine with the technology of high energy cyclotron system.”

Cyclotrons^® 18/9 is a fixed-energy cyclotron that accelerates negative ions up to 18 MeV and deuteron ions up to 10 MeV.

Enhance

The Cyclotrons^® 18/9 offers the most vital success factors:
* Operational and cost efficiency
* Safety and comfort

Discover

* A full range of target technology
* External beam line for research
* Worldwide research network

Integrate

IntegraLab Global solution

Customer Voice
Thomas Tuchyna
Cyclotron Manager
Sir Charles Gairdner Hospital, Perth, Australia

“The IBA Cyclotrons^® 18/9 has met our Centre’s expectations as a reliable and a stable machine, producing ample radioisotopes for our existing customers. The Cyclotrons^® 18/9 has sufficient capacity and flexibility to continue to meet increased isotope demand.”

Cyclotrons^® 18 Twin is a fixed-energy cyclotron that hosts two proton ion sources that accelerates negative ions up to 18 MeV.

Double life

The Cyclotrons^® 18 Twin’s has been designed in order to host two new proton ion sources, benefiting from all the other features of the Cyclotrons^® 18 family.

Increased reliability

These unique dual proton sources feature strongly increase uptime and reliability of production. Switching to a second spare source during production is simple, fast and completely automated.

Reduced maintenance

Thanks to its twin system, the global ion source lifetime is greatly extended, number of maintenance interventions is reduced and personnel exposure further limited.

Customer Voice
Isabel Ramírez de Arellano
Technical Management
BARNATRÓN

"Upgrading our FDG facility we have chosen the Cyclotrons^® 18 Twin to reduce the running costs of our center. The continuous operation, by means of subsequently running the two proton sources, led to a reduction of the maintenance cycles and cutback on unscheduled cyclotron downtime."

Cyclotrons^® 30 is a fixed-energy cyclotron that accelerates negative ions up to 30 MeV capable to deliver dual proton beam.

Best Science

* Highest beam stability
* Compact magnet structure.

Best Support

* User friendly control system
* Low maintenance concept.

Best Success

* Minimum coil ampere- turns
* Low power consumption
* Low cooling requirements.

Cyclotrons^® XP range of cyclotrons is the perfect tool for production of the new generation of medical radioisotopes in the field of diagnosis and therapy and research works.

Best Science

* Energy range : 30 MeV and 70 MeV
* Multi-particles : proton, deuteron and alpha beams
* Variable energy extraction for proton and deuteron beam.

Best Support

* User friendly control system
* Low maintenance concept.

Best Success

* Minimum coil ampere- turns
* Low power consumption
* Low cooling requirements

Customer Voice
Jean-François Chatal
Nuclear medecine professor
Cancer research
centre Inserm-university
Nantes-Anger

"We considered that IBA, recognized for its ability in the design and the realization of medical use cyclotrons, has all the assets to conceive, assemble and install this new type of last generation cyclotron."

Cyclotrons^® 70 is a fixed-energy cyclotron that accelerates negative ions up to 70 MeV capable to deliver dual proton and alpha beam.

Best Science

* Highest beam stability
* Compact magnet structure.

Best Support

* User friendly control system
* Low maintenance concept.

Best Success

* Minimum coil ampere- turns
* Low power consumption
* Low cooling requirements.

Customer Voice
Jean-François Chatal
Nuclear medecine professor
Cancer research centre Inserm-university Nantes- Anger

"We considers that IBA, recognized for its ability in the design and the realization of medical use cyclotrons, has all the assets to conceive, assemble and install this new type of last generation cyclotron."

Vectio^® is an external transport beam line that can be intalled in the IBA Cyclotrons^® family.

Best Science

* High performances on high power solid target for Tl/Ga as well as high power Xe/123I gas target
* Superior optical quality
* Maximum flexibility in beam optics

Best Support

* Maximum availability and trouble free operation
* Easy adaptation of large size targets and Cyclotrons^®
* Possibility to work safely on other targets while the cyclotron is in operation

Best Success

* Ability to increase your research and development capacity for
the development of new tracers
* The major PET and SPECT radio- isotopes manufacturer have chosen the Vectio^® beam line for their applications

Customer Voice
Celestino Ignacio
Sanchez- Angulo
Technical director
Centro Nacional de Aceleradores CNA
Sevilla, Spain

"We at CNA decided to fit our new Cyclotrons^® 18/9 with a long beam transport line to irradiate our physics experimental setup with a goof quality beam.

The beam line was configured by CNA and IBA experts as a natural extension of one of the cyclotron beam ports, while keeping available the other seven beam ports for PET radionuclides production. The experimental projects currently under development include ion implantation, radiation effects on semiconductors, and high energy PIXE."

Gas irradiation system for the production of ¹⁵O₂ or C¹⁵O , depending on carrier used.

Best Science

* Automatic gas routing to chemistry module or direct to camera for inhalation studies
* Inexpensive target material (with deuteron beam)

Best Support

* Simple and rapid process for high activity output
* Two chemical forms can be quantitatively recovered: O₂ or CO₂
* Low maintenance requirements

Best Success

* Cost-effective solution (inexpensive target material gas (¹⁴N₂)
* Elevated flow rate for high throughput (up to 500 mCi/min)

Gas irradiation system for the production of ¹⁵O₂ or C¹⁵O , depending on carrier used.

Best Science

* Automatic gas routing to chemistry module or direct to camera for inhalation studies
* Inexpensive target material (with deuteron beam)

Best Support

* Simple and rapid process for high activity output
* Two chemical forms can be quantitatively recovered: O₂ or CO₂
* Low maintenance requirements

Best Success

* Cost-effective solution (inexpensive target material gas (¹⁴N₂))
* Elevated flow rate for high throughput (up to 500 mCi/min)

Nirta^® Solid is a compact irradiation system for the production of non-conventional radioisotopes (¹²⁴I, ¹²³I, ⁶⁴Cu, ⁷⁶Br, ⁸⁶Y, ⁸⁹Zr, ⁶⁶Ga, ⁶⁷Ga, ¹¹¹In, ¹⁶⁵Er)

Best Science

* Suitable for research
* Ideal for production of non conventional PET radioisotopes based on solid target technology

Best Support

* Safe to use
* Industrial stand alone automated system
* Easy to install on existing cyclotrons

Best Success

* Simple for production
* Used today for 124I commercial production for up to 100 mCi per batch

Customer Voice
Gerd-J.Beyer
Prof.Dr., Radiochemist

"The wide distribution of PET cyclotrons will lead to a decentralized production of valuable medical isotopes that were formerly either the domain of large production centers or not available at all."

Synthesizer module for the thermo chromatographic separation of radionuclides of iodine (¹²³I and ¹²³ I) from highly enriched TeO2 targets.

Best Science

* Automatic, semi- automatic and manual control options
* Safe recovery with negligible loss of target material (< 1 % per production)
* Simple flow-through chemistry for ¹²³I final recovery

Best Support

* Easy disconnection system for maintenance and repair
* PLC Controlled and user Interface to Cyclotrons^® 30
* Full compatibility with the CCyclotrons^® 30

Best Success

* Target technology for routine production (range of target operation of 60-70 mA effective beam)
* Quantitative recovery yieds of ultra-pure ¹²³I ( radiochemical purity> 98 %)

Liquid irradiation system for the production of fluoride (¹⁸F¯) from highly

Best Science

Optimum ergonomy of use:
* Quick disconnect for easy maintenance
* Low material activation
* Minimum blocking in transfer piping

Best Support

Available with a wide range of volume and capacity for efficient use of enriched water

Best Success

Nirta^® Fluor target technology allows:
* Up to ¹³Ci of ¹⁸F - per run
* More than ⁴Ci of ¹⁸F - in ~ 30 min

Customer Voice
Piet van der Jagt, CEO
BV Cyclotron VU
Vrije Universiteit Amsterdam

"These ¹⁸F targets of the new generation are the perfect answer to the increasing need of capacity of our commercial FDG production center: high reliability and efficiency. We are currently operating the 2XL target type on a day-to-day basis."

Gas irradiation system for the production of ¹¹CH₄ or ¹¹CO₂ from nitrogen gas.

Best Science

Pressure regulator and outlet valves designed to assure smooth release of irradiated gases

Best Support

* Safe to use
* Two chemical form can be recovered CH₄/CO₂

Best Success

* High-capacity system
* Able to produce of ¹Ci CH₄ and ³Ci CO₂

Liquid irradiation system for the production of ¹²N-Ammonia directly in the target.

Best Science

* In-target direct synthesis of ammonia (NH₃)
* External filter removing traces of NOx for maximum chemical purity

Best Support

* Safe to use
* On-line’ processing of irradiated water

Best Success

* Nirta Liquid technology is able to reliably produce of 400 m Ci NH₃ in 15 min. only
* High radiochemical purity ( > 95 %) of final product

Liquid irradiation system for the production of fluoride (¹⁸F¯) from highly enriched water (H₂¹⁸O).

Best Science

* High pressure target for better performance
* Use of inexpensive target material via ²⁰Ne(d,a)¹⁸F reaction
* Minimum loss (< 5 %) during transfer

Best Support

* Production flexibility: ¹⁸F₂ can be produced via ²⁰Ne(d,a)¹⁸F or ¹⁸O(p,n)¹⁸F
* Significant recovery of target material after irradiation if expensive enriched ¹⁸O₂ used
* Superior performance with one recovery shot ready for chemistry (for proton beam)

Best Success

Nirta fluorine technology is able to reliably produce
* 250 m Ci (deuteron particle) of ¹⁸F2 in 1 h
* 1.2 Ci (proton paticle) of ¹⁸F₂ in 1 h
Capable to attain the lowest cost/run (yields fivefold higher at the same cost for proton beam)

Liquid irradiation system for the production of fluoride (¹⁸F¯) from highly enriched water (H₂¹⁸O).

Best Science

* High pressure target for better performance
* Use of inexpensive target material via ²⁰Ne(d,a)¹⁸F reaction
* Minimum loss (< 5 %) during transfer

Best Support

* Production flexibility: ¹⁸F₂ can be produced via ²⁰Ne(d,a)¹⁸F or ¹⁸O(p,n)¹⁸F
* Significant recovery of target material after irradiation if expensive enriched ¹⁸O₂ used
* Superior performance with one recovery shot ready for chemistry (for proton beam)

Best Success

Nirta fluorine technology is able to reliably produce
* 250 m Ci (deuteron particle) of ¹⁸F₂ in 1 h
* 1.2 m Ci (proton paticle) of ¹⁸F₂ in 1 h
Capable to attain the lowest cost/run (yields fivefold higher at the same cost for proton beam)

Zephiros^® control system is an user-friendly software that controls the Cyclotrons^® 18/9 and Cyclotrons^® 18 Twin.

Best Science

* Multiple user interfaces
* Unlimited number of connections
* Tremendous flexibility.

Best Support

* Remote diagnosis
* Alarm SMS Notification.

Best Success

* Production data records
* Autostart capability
* The delays and downtime highly reduced thanks to the immediate notification of the blocking problems.

IntegraLab^® is a global solution combining products and services for the production of radiopharmaceuticals.

IntegraLab^® includes among others, building design according to cGMP and the selection, integration, supply and installation of suitable equipment to match customer’s radioisotopes production goals.

Define

¹⁸F Capacity and new Radiotracers

Production solutions for SPECT & PET

High capacity cyclotron and targetry system
Full range of chemistry systems for radiopharmaceuticals and radiolabeled compounds

Financial solutions

Providing investment/financing via our network of financial partners

Comply

Regulations and Safety

GMP Facility design

• Customized and optimized facility layout, compliant with GMP standards
• Facility, architectural and engineering services such as HVAC design

Radiation Safety

• Monte carlo shielding simulation report
• Radiation monitoring and radiation protection equipment

Environmental Impact

• Radioactive waste management
• Decommissioning guidelines

Design

Select and Integrate

Clean Room Expertise

Integration of radiopharmaceutical laboratories requirements with special techniques (air classification and ventilation)

Process Equipment

• User requirements for specialized radiopharmaceuticals production process equipment
• Supply of production and quality control equipment with Pharmacopeia

GMP Certification

Standard required GMP procedures in terms of quality assurance and regulatory aspects

Validation Master Plan

Development of customized validation master plane (VMP)

Build

On time and budget

Material Qualification

Protocols for:
• Installation Qualification (IQ)
• Operational Qualification (OQ)
• Performance Qualification (PQ)

Process Validation

• Customized standard operation procedures (SOPs) for quality system elaboration and site master file (SMF)
• Elaboration of calibration, validation and preventive maintenance programs

FDG Market authorization

• Guidance to obtain global market authorization
• Deliverables based on IBA dossier

Run

Training and Support

Technical consulting support

• On-site technical support from IBA experts in GMP or/and regulatory affairs Training
• Extensive training programs for equipment operation and maintenance
• GMP training on site or/and at IBA production centers

Endless innovation

• Participate in the IBA international VIP Collaboration Network
• Delivery of new tracers and automated production systems to cover your R&D needs